Loren Pickart, Ph.D.
Skin Biology Research
Underlying GHK-Cu dermal-signaling research.
GLOW is a compounded injectable aesthetic formulation packaged as a 70 mg vial combining GHK-Cu, reduced L-glutathione (GSH), and ascorbic acid (Vitamin C). It targets skin density, dermal texture, hyperpigmentation, and oxidative-stress reduction. A 2025 systematic review flagged IV/systemic glutathione as having insufficient efficacy data and elevated adverse-event risk, and no RCTs have evaluated this specific three-ingredient mixture.
Mechanism of action
- GHK-Cu: dermal gene modulation supporting collagen and elastin pathways.
- L-Glutathione: intracellular antioxidant with proposed melanogenesis-modulating effects.
- Vitamin C: cofactor for collagen hydroxylation and reactive oxygen species control.
Research highlights
- 2025 systematic review flagged IV/systemic glutathione data as insufficient.
- No RCTs have evaluated the specific GHK-Cu + GSH + Vitamin C combination.
Regulatory note: No RCTs have evaluated this specific three-ingredient mixture, and IV glutathione carries documented adverse-event signals.