Gabriel Sosne, M.D.
Wayne State University / Kresge Eye Institute
Lead expert in Tβ4 corneal repair; Annals NY Acad. Sci. (2012) review.
TB-500 is a synthetic fragment of Thymosin Beta-4 (Tβ4), an endogenous 43-amino acid protein found in virtually all human tissues. It regulates actin polymerization, enabling rapid cell migration to injury sites, and stimulates angiogenesis to restore blood flow to damaged tissue. Human clinical trials have confirmed efficacy in corneal wound healing.
Mechanism of action
- Binds G-actin, regulating cytoskeletal organization and cell migration.
- Promotes angiogenesis and recruitment of progenitor cells to injured tissue.
- Modulates inflammatory signaling in corneal, dermal, and musculoskeletal repair models.
Research highlights
- Human clinical trials on Tβ4 demonstrated efficacy in dry eye and corneal wound healing.
- Annals NY Academy of Sciences (2012) review by Sosne summarized Tβ4 corneal repair data.
- Foundational work by Allan Goldstein led to the discovery of Thymosin Beta-4.